The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

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The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.

Liraglutide is a glucagon-like peptide-1 (GLP-1) analog marketed for the treatment of type 2 diabetes. Besides lowering blood glucose, liraglutide also reduces body weight. It is not fully understood how liraglutide induces weight loss or to what degree liraglutide acts directly in the brain. Here, we determined that liraglutide does not activate GLP-1-producing neurons in the hindbrain, and li...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 2014

ISSN: 0021-9738

DOI: 10.1172/jci75276